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Context also plays a critical role in understanding what may be causing your symptoms, says Kiran Mullur, MD, a family medicine and sports medicine physician at Atrium Wake Forest in Kernersville, North Carolina

Native human GLP-1 has a very short half-life of approximately 2 minutes due to rapid degradation primarily by the enzyme dipeptidyl peptidase-4 (DPP-4), with neutral endopeptidase (NEP) also contributing to its breakdown

Thats around 80 to 120 grams a day if you weigh 175 pounds

Instead, theyre calling for more research, citing that existing evidence is currently inadequate